Blar i forfatter "Dorraji, Seyed Esmaeil"

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    • Kidney tertiary lymphoid structures in Lupus Nephritis develop into large interconnected networks and resemble lymph nodes in gene signature 

      Dorraji, Seyed Esmaeil; Kanapathippillai, Premasany; Hovd, Aud-Malin Karlsson; Stenersrød, Mikael Ryan; Horvei, Kjersti Daae; Ursvik, anita; Figenschau, Stine; Thiyagarajan, Dhivya Borra; Fenton, Christopher Graham; Pedersen, Hege Lynum; Fenton, Kristin Andreassen (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-08-16)
      Immune aggregates organized as tertiary lymphoid structures (TLS) are observed within the kidneys of patients with systemic lupus erythematosus and lupus nephritis (LN). Renal TLS was characterized in lupus-prone New Zealand black × New Zealand white F1 mice analyzing cell composition and vessel formation. RNA sequencing was performed on transcriptomes isolated from lymph nodes, macrodissected TLS ...

    • Machine learning derived input-function in a dynamic 18F-FDG PET study of mice 

      Kuttner, Samuel; Wickstrøm, Kristoffer Knutsen; Kalda, Gustav; Dorraji, Seyed Esmaeil; Martin-Armas, Montserrat; Oteiza, Ana; Jenssen, Robert; Fenton, Kristin Andreassen; Sundset, Rune; Axelsson, Jan (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-13)
      Tracer kinetic modelling, based on dynamic <sup>18</sup>F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is used to quantify glucose metabolism in humans and animals. Knowledge of the arterial input-function (AIF) is required for such measurements. Our aim was to explore two non-invasive machine learning-based models, for AIF prediction in a small-animal dynamic FDG PET study. 7 tissue ...

    • Mesenchymal stem cells and T cells in the formation of Tertiary Lymphoid Structures in Lupus Nephritis 

      Dorraji, Seyed Esmaeil; Hovd, Aud-Malin Karlsson; Kanapathippillai, Premasany; Bakland, Gunnstein; Eilertsen, Gro Østli; Figenschau, Stine; Fenton, Kristin Andreassen (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-05-18)
      Tertiary lymphoid structures (TLS) develop in the kidneys of lupus-prone mice and systemic lupus erythematosus (SLE) patients with lupus nephritis (LN). Here we investigated the presence of mesenchymal stem cells (MSCs) in the development of TLS in murine LN, as well as the role of human MSCs as lymphoid tissue organizer (LTo) cells on the activation of CD4+ T cells from three groups of donors ...

    • Positron emission tomography and single photon emission computed tomography imaging of tertiary lymphoid structures during the development of lupus nephritis 

      Dorraji, Seyed Esmaeil; Oteiza, Ana; Kuttner, Samuel; Martin, Armas Maria Montserrat; Kanapathippillai, Premasany; Garbarino, Sara; Kalda, Gustav; Scussolini, Mara; Piana, Michele; Fenton, Kristin Andreassen (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-03)
      Lymphoid neogenesis occurs in tissues targeted by chronic inflammatory processes, such as infection and autoimmunity. In systemic lupus erythematosus (SLE), such structures develop within the kidneys of lupus-prone mice ((NZBXNZW)F1) and are observed in kidney biopsies taken from SLE patients with lupus nephritis (LN). The purpose of this prospective longitudinal animal study was to detect early ...